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Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization.

Publication ,  Journal Article
Kelly, SM; Raudales, R; He, M; Lee, JH; Kim, Y; Gibb, LG; Wu, P; Matho, K; Osten, P; Graybiel, AM; Huang, ZJ
Published in: Neuron
July 25, 2018

The circuitry of the striatum is characterized by two organizational plans: the division into striosome and matrix compartments, thought to mediate evaluation and action, and the direct and indirect pathways, thought to promote or suppress behavior. The developmental origins of these organizations and their developmental relationships are unknown, leaving a conceptual gap in understanding the cortico-basal ganglia system. Through genetic fate mapping, we demonstrate that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitors (IPs). The early phase of this program produces striosomal spiny projection neurons (SPNs) through fate-restricted apical IPs (aIPSs) with limited capacity; the late phase produces matrix SPNs through fate-restricted basal IPs (bIPMs) with expanded capacity. Notably, direct and indirect pathway SPNs arise within both aIPS and bIPM pools, suggesting that striosome-matrix architecture is the fundamental organizational plan of basal ganglia circuitry.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

July 25, 2018

Volume

99

Issue

2

Start / End Page

345 / 361.e4

Location

United States

Related Subject Headings

  • Stem Cells
  • Pregnancy
  • Neurology & Neurosurgery
  • Neuroglia
  • Nerve Net
  • Mice, Transgenic
  • Mice, 129 Strain
  • Mice
  • Male
  • Female
 

Citation

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Chicago
ICMJE
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Kelly, S. M., Raudales, R., He, M., Lee, J. H., Kim, Y., Gibb, L. G., … Huang, Z. J. (2018). Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron, 99(2), 345-361.e4. https://doi.org/10.1016/j.neuron.2018.06.021
Kelly, Sean M., Ricardo Raudales, Miao He, Jannifer H. Lee, Yongsoo Kim, Leif G. Gibb, Priscilla Wu, et al. “Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization.Neuron 99, no. 2 (July 25, 2018): 345-361.e4. https://doi.org/10.1016/j.neuron.2018.06.021.
Kelly SM, Raudales R, He M, Lee JH, Kim Y, Gibb LG, et al. Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron. 2018 Jul 25;99(2):345-361.e4.
Kelly, Sean M., et al. “Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization.Neuron, vol. 99, no. 2, July 2018, pp. 345-361.e4. Pubmed, doi:10.1016/j.neuron.2018.06.021.
Kelly SM, Raudales R, He M, Lee JH, Kim Y, Gibb LG, Wu P, Matho K, Osten P, Graybiel AM, Huang ZJ. Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron. 2018 Jul 25;99(2):345-361.e4.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

July 25, 2018

Volume

99

Issue

2

Start / End Page

345 / 361.e4

Location

United States

Related Subject Headings

  • Stem Cells
  • Pregnancy
  • Neurology & Neurosurgery
  • Neuroglia
  • Nerve Net
  • Mice, Transgenic
  • Mice, 129 Strain
  • Mice
  • Male
  • Female