Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates.

Journal Article (Journal Article)

Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. Here, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 μg of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. mRNA-1273 vaccination elicited circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs after SARS-CoV-2 challenge in vaccinated animals and most strongly correlated with levels of anti–S antibody and neutralizing activity. Lower antibody levels were needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273–induced immunoglobulin G to naïve hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccine–induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs.

Full Text

Duke Authors

Cited Authors

  • Corbett, KS; Nason, MC; Flach, B; Gagne, M; O'Connell, S; Johnston, TS; Shah, SN; Edara, VV; Floyd, K; Lai, L; McDanal, C; Francica, JR; Flynn, B; Wu, K; Choi, A; Koch, M; Abiona, OM; Werner, AP; Moliva, JI; Andrew, SF; Donaldson, MM; Fintzi, J; Flebbe, DR; Lamb, E; Noe, AT; Nurmukhambetova, ST; Provost, SJ; Cook, A; Dodson, A; Faudree, A; Greenhouse, J; Kar, S; Pessaint, L; Porto, M; Steingrebe, K; Valentin, D; Zouantcha, S; Bock, KW; Minai, M; Nagata, BM; van de Wetering, R; Boyoglu-Barnum, S; Leung, K; Shi, W; Yang, ES; Zhang, Y; Todd, J-PM; Wang, L; Alvarado, GS; Andersen, H; Foulds, KE; Edwards, DK; Mascola, JR; Moore, IN; Lewis, MG; Carfi, A; Montefiori, D; Suthar, MS; McDermott, A; Roederer, M; Sullivan, NJ; Douek, DC; Graham, BS; Seder, RA

Published Date

  • September 17, 2021

Published In

Volume / Issue

  • 373 / 6561

Start / End Page

  • eabj0299 -

PubMed ID

  • 34529476

Pubmed Central ID

  • PMC8449013

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.abj0299

Language

  • eng

Conference Location

  • United States