A Modern-World View of Host-Microbiota-Pathogen Interactions.

Journal Article (Review;Journal Article)

The microbiota-the diverse set of commensal microbes that normally colonize humans-represents the first line of defense against infectious diseases. In this review, we summarize the direct and indirect mechanisms by which the microbiota modulates susceptibility to, and severity of, infections, with a focus on immunological mechanisms. Moreover, we highlight some of the ways that modern-world lifestyles have influenced the structure-function relationship between the microbiota and infectious diseases. Ultimately, understanding how the microbiota influences infectious risks will facilitate development of microbiota-derived therapeutics that bolster host defenses.

Full Text

Duke Authors

Cited Authors

  • Tan, CY; Ramirez, ZE; Surana, NK

Published Date

  • October 2021

Published In

Volume / Issue

  • 207 / 7

Start / End Page

  • 1710 - 1718

PubMed ID

  • 34544813

Pubmed Central ID

  • PMC8462030

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.2100215

Language

  • eng