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Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.

Publication ,  Journal Article
Alick, CL; Maguire, RL; Murphy, SK; Fuemmeler, BF; Hoyo, C; House, JS
Published in: Nutrients
September 13, 2021

Maternal periconceptional diets have known associations with proper offspring neurodevelopment. Mechanisms for such associations include improper energy/nutrient balances between mother and fetus, as well as altered offspring epigenetics during development due to maternal nutrient and inflammatory status. Using a comprehensive food frequency questionnaire and assessing offspring temperament with the Infant-Toddler Social and Emotional Assessment (n = 325, mean age = 13.9 months), we sought to test whether a maternal periconceptional diet characterized by high glycemic loading (MGL) would affect offspring temperament using adjusted ordinal regression. After limiting false discovery to 10%, offspring born to mothers in tertile 3 of glycemic loading (referent = tertile 1) were more likely to be in the next tertile of anxiety [OR (95% CI) = 4.51 (1.88-11.07)] and inhibition-related behaviors [OR (95% CI) = 3.42 (1.49-7.96)]. Male offspring were more likely to exhibit impulsive [OR (95% CI) = 5.55 (1.76-18.33)], anxiety [OR (95% CI) = 4.41 (1.33-15.30)], sleep dysregulation [OR (95% CI) = 4.14 (1.34-13.16)], empathy [6.68 (1.95-24.40)], and maladaptive behaviors [OR (95% CI) = 9.86 (2.81-37.18)], while females were more likely to exhibit increased anxiety-related behaviors [OR (95% CI) = 15.02 (3.14-84.27)]. These associations persisted when concurrently modeled with the maternal-Mediterranean dietary pattern. In a subset (n = 142), we also found MGL associated with increased mean methylation of the imprint control region of SGCE/PEG10. In conclusion, these findings highlight the importance of maternal dietary patterns on offspring neurodevelopment, offering avenues for prevention options for mothers.

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Published In

Nutrients

DOI

EISSN

2072-6643

Publication Date

September 13, 2021

Volume

13

Issue

9

Location

Switzerland

Related Subject Headings

  • Temperament
  • Sex Factors
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Maternal Nutritional Physiological Phenomena
  • Male
  • Infant Behavior
  • Infant
  • Impulsive Behavior
  • Humans
 

Citation

APA
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MLA
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Alick, C. L., Maguire, R. L., Murphy, S. K., Fuemmeler, B. F., Hoyo, C., & House, J. S. (2021). Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST. Nutrients, 13(9). https://doi.org/10.3390/nu13093180
Alick, Candice L., Rachel L. Maguire, Susan K. Murphy, Bernard F. Fuemmeler, Cathrine Hoyo, and John S. House. “Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.Nutrients 13, no. 9 (September 13, 2021). https://doi.org/10.3390/nu13093180.
Alick CL, Maguire RL, Murphy SK, Fuemmeler BF, Hoyo C, House JS. Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST. Nutrients. 2021 Sep 13;13(9).
Alick, Candice L., et al. “Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.Nutrients, vol. 13, no. 9, Sept. 2021. Pubmed, doi:10.3390/nu13093180.
Alick CL, Maguire RL, Murphy SK, Fuemmeler BF, Hoyo C, House JS. Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST. Nutrients. 2021 Sep 13;13(9).

Published In

Nutrients

DOI

EISSN

2072-6643

Publication Date

September 13, 2021

Volume

13

Issue

9

Location

Switzerland

Related Subject Headings

  • Temperament
  • Sex Factors
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Maternal Nutritional Physiological Phenomena
  • Male
  • Infant Behavior
  • Infant
  • Impulsive Behavior
  • Humans