Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.

Journal Article (Journal Article)

Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.

Full Text

Duke Authors

Cited Authors

  • Xi, W; Hegde, V; Zoller, SD; Park, HY; Hart, CM; Kondo, T; Hamad, CD; Hu, Y; Loftin, AH; Johansen, DO; Burke, Z; Clarkson, S; Ishmael, C; Hori, K; Mamouei, Z; Okawa, H; Nishimura, I; Bernthal, NM; Segura, T

Published Date

  • September 16, 2021

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 5473 -

PubMed ID

  • 34531396

Pubmed Central ID

  • PMC8445967

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

International Standard Serial Number (ISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-021-25383-z

Language

  • eng