Influence of editing pulse flip angle on J-difference MR spectroscopy.

Journal Article (Journal Article)

PURPOSE: To investigate the editing-pulse flip angle (FA) dependence of editing efficiency and ultimately to maximize the edited signal of commonly edited MR spectroscopy (MRS) signals, such as gamma-aminobutyric acid (GABA) and lactate. METHODS: Density-matrix simulations were performed for a range of spin systems to find the editing-pulse FA for maximal editing efficiency. Simulations were confirmed by phantom experiments and in vivo measurements in 10 healthy participants using a 3T Philips scanner. Four MEGA-PRESS in vivo measurements targeting GABA+ and lactate were performed, comparing the conventional editing-pulse FA (FA = 180°) to the optimal one suggested by simulations (FA = 210°). RESULTS: Simulations and phantom experiments show that edited GABA and lactate signals are maximal at FA = 210°. Compared to conventional editing (FA = 180°), in vivo signals from GABA+ and lactate signals increase on average by 8.5% and 9.3%, respectively. CONCLUSION: Increasing the FA of editing-pulses in the MEGA-PRESS experiment from 180° to 210° increases the edited signals from GABA+ and lactate by about 9% in vivo.

Full Text

Duke Authors

Cited Authors

  • Tapper, S; Hui, SCN; Saleh, MG; Zöllner, HJ; Oeltzschner, G; Near, J; Soher, BJ; Edden, RAE

Published Date

  • February 2022

Published In

Volume / Issue

  • 87 / 2

Start / End Page

  • 589 - 596

PubMed ID

  • 34520079

Pubmed Central ID

  • PMC8627430

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

Digital Object Identifier (DOI)

  • 10.1002/mrm.29008


  • eng

Conference Location

  • United States