Skip to main content
Journal cover image

Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use.

Publication ,  Journal Article
Guthrie, KM; Rosen, RK; Guillen, M; Ramirez, JJ; Vargas, SE; Fava, JL; Ham, AS; Katz, DF; Cu-Uvin, S; Tumilty, S; Smith, KA; Buckheit, KW ...
Published in: AIDS research and human retroviruses
July 2022

Dual compartment suppositories are being developed to prevent HIV and other sexually transmitted infections. Such products, for use in the rectum, the vagina, or both, could have a significant public health impact by decreasing global incidence of these diseases. In this study, 16 women each used two rheologically distinct suppositories in their vagina and rectum. User Sensory Perception and Experience (USPE) scales assessed sensory experiences during sexual activity to understand whether, and how, women perceive formulation properties in the vagina and rectum. Qualitative data from individual in-depth interviews captured women's descriptions and comparisons of the experiences. Significant differences and large Cohen's d effect sizes between vaginal and rectal experiences of suppository-A were found for three scales: Application (APP): Product Awareness, SEX: Initial Penetration; and SEX: Effortful. Qualitative data provided user experience details that credibly align with these score differences. Near significant differences and large effect sizes were found for two additional scales: SEX: Perceived Wetness with suppository-A and SEX: Messiness with suppository-B. In addition, other scale scores showed medium-to-large effect sizes that correspond to hypothesized sensations associated with biophysical properties of the suppositories. Statistical significance combined with large effect sizes and qualitative data accurately represent the hypothesized perceptibility of suppository properties and identifies performance characteristics relevant to acceptability and adherence; together these data provide discernment of factors that can guide the development of dual compartment products. The Clinical Trial Registration number: NCT02744261.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

AIDS research and human retroviruses

DOI

EISSN

1931-8405

ISSN

0889-2229

Publication Date

July 2022

Volume

38

Issue

7

Start / End Page

601 / 610

Related Subject Headings

  • Virology
  • Suppositories
  • Sensation
  • Rectum
  • Humans
  • HIV Infections
  • Female
  • Administration, Intravaginal
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guthrie, K. M., Rosen, R. K., Guillen, M., Ramirez, J. J., Vargas, S. E., Fava, J. L., … Buckheit, R. W. (2022). Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use. AIDS Research and Human Retroviruses, 38(7), 601–610. https://doi.org/10.1089/aid.2021.0038
Guthrie, Kate M., Rochelle K. Rosen, Melissa Guillen, Jaime J. Ramirez, Sara E. Vargas, Joseph L. Fava, Anthony S. Ham, et al. “Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use.AIDS Research and Human Retroviruses 38, no. 7 (July 2022): 601–10. https://doi.org/10.1089/aid.2021.0038.
Guthrie KM, Rosen RK, Guillen M, Ramirez JJ, Vargas SE, Fava JL, et al. Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use. AIDS research and human retroviruses. 2022 Jul;38(7):601–10.
Guthrie, Kate M., et al. “Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use.AIDS Research and Human Retroviruses, vol. 38, no. 7, July 2022, pp. 601–10. Epmc, doi:10.1089/aid.2021.0038.
Guthrie KM, Rosen RK, Guillen M, Ramirez JJ, Vargas SE, Fava JL, Ham AS, Katz DF, Cu-Uvin S, Tumilty S, Smith KA, Buckheit KW, Buckheit RW. Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use. AIDS research and human retroviruses. 2022 Jul;38(7):601–610.
Journal cover image

Published In

AIDS research and human retroviruses

DOI

EISSN

1931-8405

ISSN

0889-2229

Publication Date

July 2022

Volume

38

Issue

7

Start / End Page

601 / 610

Related Subject Headings

  • Virology
  • Suppositories
  • Sensation
  • Rectum
  • Humans
  • HIV Infections
  • Female
  • Administration, Intravaginal
  • 3202 Clinical sciences
  • 1103 Clinical Sciences