Neuromodulatory Control of Early Visual Processing in Macaque.

Journal Article (Review;Journal Article)

Visual processing is dynamically controlled by multiple neuromodulatory molecules that modify the responsiveness of neurons and the strength of the connections between them. In particular, modulatory control of processing in the lateral geniculate nucleus of the thalamus, V1, and V2 will alter the outcome of all subsequent processing of visual information, including the extent to and manner in which individual inputs contribute to perception and decision making and are stored in memory. This review addresses five small-molecule neuromodulators-acetylcholine, dopamine, serotonin, noradrenaline, and histamine-considering the structural basis for their action, and the effects of their release, in the early visual pathway of the macaque monkey. Traditionally, neuromodulators are studied in isolation and in discrete circuits; this review makes a case for considering the joint action of modulatory molecules and differences in modulatory effects across brain areas as a better means of understanding the diverse roles that these molecules serve.

Full Text

Duke Authors

Cited Authors

  • Disney, AA

Published Date

  • September 2021

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 181 - 199

PubMed ID

  • 34524875

Electronic International Standard Serial Number (EISSN)

  • 2374-4650

International Standard Serial Number (ISSN)

  • 2374-4642

Digital Object Identifier (DOI)

  • 10.1146/annurev-vision-100119-125739


  • eng