The past, present, and future of enzyme-based therapies.

Journal Article (Review;Journal Article)

Enzyme-based therapeutics (EBTs) have the potential to tap into an almost unmeasurable amount of enzyme biodiversity and treat myriad conditions. Although EBTs were some of the first biologics used clinically, the rate of development of newer EBTs has lagged behind that of other biologics. Here, we review the history of EBTs, and discuss the state of each class of EBT, their potential clinical advantages, and the unique challenges to their development. Additionally, we discuss key remaining technical barriers that, if addressed, could increase the diversity and rate of the development of EBTs.

Full Text

Duke Authors

Cited Authors

  • Hennigan, JN; Lynch, MD

Published Date

  • January 2022

Published In

Volume / Issue

  • 27 / 1

Start / End Page

  • 117 - 133

PubMed ID

  • 34537332

Pubmed Central ID

  • PMC8714691

Electronic International Standard Serial Number (EISSN)

  • 1878-5832

International Standard Serial Number (ISSN)

  • 1359-6446

Digital Object Identifier (DOI)

  • 10.1016/j.drudis.2021.09.004


  • eng