T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation.
Journal Article (Journal Article)
ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells residing in nonlymphoid tissues, and these cells can potently expand upon provision of exogenous IL-33. Whether the accumulation and residence of T reg cells in tissues requires their cell-intrinsic expression of and signaling by ST2, or whether indirect IL-33 signaling acting on other cells suffices, has been a matter of contention. Here, we report that ST2 expression on T reg cells is largely dispensable for their accumulation and residence in nonlymphoid organs, including the visceral adipose tissue (VAT), even though cell-intrinsic sensing of IL-33 promotes type 2 cytokine production by VAT-residing T reg cells. In addition, we uncovered a novel ST2-dependent role for T reg cells in limiting the size of IL-17A-producing γδT cells in the CNS in a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Finally, ST2 deficiency limited to T reg cells led to disease exacerbation in EAE.
Full Text
Duke Authors
Cited Authors
- Hemmers, S; Schizas, M; Rudensky, AY
Published Date
- February 1, 2021
Published In
Volume / Issue
- 218 / 2
PubMed ID
- 33095261
Pubmed Central ID
- PMC7590508
Electronic International Standard Serial Number (EISSN)
- 1540-9538
Digital Object Identifier (DOI)
- 10.1084/jem.20201234
Language
- eng
Conference Location
- United States