A Distinct Function of Regulatory T Cells in Tissue Protection.

Journal Article (Journal Article)

Regulatory T (Treg) cells suppress immune responses to a broad range of non-microbial and microbial antigens and indirectly limit immune inflammation-inflicted tissue damage by employing multiple mechanisms of suppression. Here, we demonstrate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decreased blood oxygen concentration during influenza virus infection without any measureable alterations in Treg cell suppressor function, antiviral immune responses, or viral load. This tissue repair modality is mobilized in Treg cells in response to inflammatory mediator IL-18 or alarmin IL-33, but not by TCR signaling that is required for suppressor function. These results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance-distinct from their role in suppression of immune responses and inflammation-and that these two essential Treg cell functions are invoked by separable cues.

Full Text

Duke Authors

Cited Authors

  • Arpaia, N; Green, JA; Moltedo, B; Arvey, A; Hemmers, S; Yuan, S; Treuting, PM; Rudensky, AY

Published Date

  • August 27, 2015

Published In

Volume / Issue

  • 162 / 5

Start / End Page

  • 1078 - 1089

PubMed ID

  • 26317471

Pubmed Central ID

  • PMC4603556

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2015.08.021

Language

  • eng

Conference Location

  • United States