Regulatory T cell ablation causes acute T cell lymphopenia.

Journal Article (Journal Article)

Regulatory T (Treg) cells enforce T cell homeostasis and maintain peripheral T cell tolerance. Here we report a previously unappreciated phenomenon of acute T cell lymphopenia in secondary lymphoid organs and non-lymphoid tissues triggered by Treg cell depletion that precedes the expansion of self-reactive T cells. Lymphopenia affects both neonates and adults indicating a dominant role of Treg cells in maintaining peripheral T cell numbers regardless of the developmental stage. The lymphopenia was neither triggered by caspase-dependent apoptosis nor macrophage-mediated clearance of T cells, nor diminished survival of naïve or recently activated T cells due to paucity of IL-7. It is possible that transient lymphopenia associated with congenital or acute Treg cell deficiency may contribute to the development of T cell mediated autoimmune disorders.

Full Text

Duke Authors

Cited Authors

  • Moltedo, B; Hemmers, S; Rudensky, AY

Published Date

  • 2014

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • e86762 -

PubMed ID

  • 24466225

Pubmed Central ID

  • PMC3900634

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0086762

Language

  • eng

Conference Location

  • United States