IL-2-dependent adaptive control of NK cell homeostasis.

Journal Article (Journal Article)

Activation and expansion of T and B lymphocytes and myeloid cells are controlled by Foxp3(+) regulatory T cells (T reg cells), and their deficiency results in a fatal lympho- and myeloproliferative syndrome. A role for T reg cells in the homeostasis of innate lymphocyte lineages remained unknown. Here, we report that T reg cells restrained the expansion of immature CD127(+) NK cells, which had the unique ability to up-regulate the IL2Rα (CD25) in response to the proinflammatory cytokine IL-12. In addition, we observed the preferential accumulation of CD127(+) NK cells in mice bearing progressing tumors or suffering from chronic viral infection. CD127(+) NK cells expanded in an IL-2-dependent manner upon T reg cell depletion and were able to give rise to mature NK cells, indicating that the latter can develop through a CD25(+) intermediate stage. Thus, T reg cells restrain the IL-2-dependent CD4(+) T cell help for CD127(+) immature NK cells. These findings highlight the adaptive control of innate lymphocyte homeostasis.

Full Text

Duke Authors

Cited Authors

  • Gasteiger, G; Hemmers, S; Bos, PD; Sun, JC; Rudensky, AY

Published Date

  • June 3, 2013

Published In

Volume / Issue

  • 210 / 6

Start / End Page

  • 1179 - 1187

PubMed ID

  • 23650439

Pubmed Central ID

  • PMC3674698

Electronic International Standard Serial Number (EISSN)

  • 1540-9538

Digital Object Identifier (DOI)

  • 10.1084/jem.20122571


  • eng

Conference Location

  • United States