Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

Journal Article (Journal Article)

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T-helper-cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune-mediated disease.

Full Text

Duke Authors

Cited Authors

  • Bonham, K; Hemmers, S; Lim, Y-H; Hill, DM; Finn, MG; Mowen, KA

Published Date

  • May 2010

Published In

Volume / Issue

  • 277 / 9

Start / End Page

  • 2096 - 2108

PubMed ID

  • 20345902

Pubmed Central ID

  • PMC2903848

Electronic International Standard Serial Number (EISSN)

  • 1742-4658

Digital Object Identifier (DOI)

  • 10.1111/j.1742-4658.2010.07623.x

Language

  • eng

Conference Location

  • England