Skip to main content

Hospitalizations in patients with idiopathic pulmonary fibrosis.

Publication ,  Journal Article
Kim, HJ; Snyder, LD; Adegunsoye, A; Neely, ML; Bender, S; White, ES; Conoscenti, CS; Strek, ME; IPF-PRO Registry Investigators,
Published in: Respir Res
September 30, 2021

BACKGROUND: Hospitalizations are common among patients with idiopathic pulmonary fibrosis (IPF). We investigated the impact of hospitalizations on outcomes in patients with IPF. METHODS: The IPF-PRO Registry is an observational US registry that enrolled patients with IPF that was diagnosed or confirmed at the enrolling center in the previous 6 months. Associations between patient characteristics and hospitalization, and between hospitalization and mortality, were analyzed using Cox regression models. RESULTS: A total of 1002 patients with IPF were enrolled into the IPF-PRO Registry. Over a median follow-up time of 23.7 months (maximum: 67.0 months), 568 patients (56.7%) had at least one hospitalization. Of these patients, 319 (56.2%) had at least one respiratory-related hospitalization and 120 (21.1%) had at least one hospitalization with ventilatory support. Younger age (HR 0.68 [95% CI 0.55, 0.84] per 5-year increase for patients < 62 years), lower BMI (0.96 [0.93, 0.98] per 1-point increase), lower FVC % predicted (0.90 [0.83, 0.97] per 10% increase), oxygen use at rest (2.85 [2.18, 3.72]) and history of pulmonary hypertension (2.02 [1.37, 2.96]) at enrollment were associated with an increased risk of respiratory-related hospitalization during follow-up. In a multivariable model, there was an eightfold increase in the risk of mortality during hospitalization or within 90 days of discharge compared with outside of this period. The risk of mortality associated with a respiratory hospitalization or a hospitalization with ventilatory support was even greater. CONCLUSIONS: Data from the IPF-PRO Registry demonstrate that hospitalizations are common among patients with IPF. The risk of mortality during hospitalization or within 90 days of discharge was high, particularly among patients who were hospitalized for a respiratory cause or received ventilatory support. Trial registration ClinicalTrials.gov, NCT01915511. Registered 5 August 2013, https://clinicaltrials.gov/ct2/show/NCT01915511.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Respir Res

DOI

EISSN

1465-993X

Publication Date

September 30, 2021

Volume

22

Issue

1

Start / End Page

257

Location

England

Related Subject Headings

  • United States
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Respiration, Artificial
  • Registries
  • Prognosis
  • Patient Readmission
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, H. J., Snyder, L. D., Adegunsoye, A., Neely, M. L., Bender, S., White, E. S., … IPF-PRO Registry Investigators, . (2021). Hospitalizations in patients with idiopathic pulmonary fibrosis. Respir Res, 22(1), 257. https://doi.org/10.1186/s12931-021-01851-4
Kim, Hyun J., Laurie D. Snyder, Ayodeji Adegunsoye, Megan L. Neely, Shaun Bender, Eric S. White, Craig S. Conoscenti, Mary E. Strek, and Mary E. IPF-PRO Registry Investigators. “Hospitalizations in patients with idiopathic pulmonary fibrosis.Respir Res 22, no. 1 (September 30, 2021): 257. https://doi.org/10.1186/s12931-021-01851-4.
Kim HJ, Snyder LD, Adegunsoye A, Neely ML, Bender S, White ES, et al. Hospitalizations in patients with idiopathic pulmonary fibrosis. Respir Res. 2021 Sep 30;22(1):257.
Kim, Hyun J., et al. “Hospitalizations in patients with idiopathic pulmonary fibrosis.Respir Res, vol. 22, no. 1, Sept. 2021, p. 257. Pubmed, doi:10.1186/s12931-021-01851-4.
Kim HJ, Snyder LD, Adegunsoye A, Neely ML, Bender S, White ES, Conoscenti CS, Strek ME, IPF-PRO Registry Investigators. Hospitalizations in patients with idiopathic pulmonary fibrosis. Respir Res. 2021 Sep 30;22(1):257.

Published In

Respir Res

DOI

EISSN

1465-993X

Publication Date

September 30, 2021

Volume

22

Issue

1

Start / End Page

257

Location

England

Related Subject Headings

  • United States
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Respiration, Artificial
  • Registries
  • Prognosis
  • Patient Readmission