Leveraging external data in the design and analysis of clinical trials in neuro-oncology.

Journal Article (Journal Article;Review)

Integration of external control data, with patient-level information, in clinical trials has the potential to accelerate the development of new treatments in neuro-oncology by contextualising single-arm studies and improving decision making (eg, early stopping decisions). Based on a series of presentations at the 2020 Clinical Trials Think Tank hosted by the Society of Neuro-Oncology, we provide an overview on the use of external control data representative of the standard of care in the design and analysis of clinical trials. High-quality patient-level records, rigorous methods, and validation analyses are necessary to effectively leverage external data. We review study designs, statistical methods, risks, and potential distortions in using external data from completed trials and real-world data, as well as data sources, data sharing models, ongoing work, and applications in glioblastoma.

Full Text

Duke Authors

Cited Authors

  • Rahman, R; Ventz, S; McDunn, J; Louv, B; Reyes-Rivera, I; Polley, M-YC; Merchant, F; Abrey, LE; Allen, JE; Aguilar, LK; Aguilar-Cordova, E; Arons, D; Tanner, K; Bagley, S; Khasraw, M; Cloughesy, T; Wen, PY; Alexander, BM; Trippa, L

Published Date

  • October 2021

Published In

Volume / Issue

  • 22 / 10

Start / End Page

  • e456 - e465

PubMed ID

  • 34592195

Pubmed Central ID

  • PMC8893120

Electronic International Standard Serial Number (EISSN)

  • 1474-5488

Digital Object Identifier (DOI)

  • 10.1016/S1470-2045(21)00488-5


  • eng

Conference Location

  • England