Reprint of: Conditional specification of endomesoderm.

Journal Article (Review;Journal Article)

Early in animal development many cells are conditionally specified based on observations that those cells can be directed toward alternate fates. The endomesoderm is so named because early specification produces cells that often have been observed to simultaneously express both early endoderm and mesoderm transcription factors. Experiments with these cells demonstrate that their progeny can directed entirely toward endoderm or mesoderm, whereas normally they establish both germ layers. This review examines the mechanisms that initiate the conditional endomesoderm state, its metastability, and the mechanisms that resolve that state into definitive endoderm and mesoderm.

Full Text

Duke Authors

Cited Authors

  • McClay, DR; Croce, JC; Warner, JF

Published Date

  • December 2021

Published In

Volume / Issue

  • 168 /

Start / End Page

  • 203731 -

PubMed ID

  • 34610899

Electronic International Standard Serial Number (EISSN)

  • 2667-2901

International Standard Serial Number (ISSN)

  • 2667-291X

Digital Object Identifier (DOI)

  • 10.1016/j.cdev.2021.203731

Language

  • eng