Review of bio-optical imaging systems with a high space-bandwidth product

Journal Article (Review;Journal)

Optical imaging has served as a primary method to collect information about biosystems across scales-from functionalities of tissues to morphological structures of cells and even at biomolecular levels. However, to adequately characterize a complex biosystem, an imaging system with a number of resolvable points, referred to as a space-bandwidth product (SBP), in excess of one billion is typically needed. Since a gigapixel-scale far exceeds the capacity of current optical imagers, compromises must be made to obtain either a low spatial resolution or a narrow field-of-view (FOV). The problem originates from constituent refractive optics-the larger the aperture, the more challenging the correction of lens aberrations. Therefore, it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions. To address this unmet need, a variety of high-SBP imagers have emerged over the past decade, enabling an unprecedented resolution and FOV beyond the limit of conventional optics. We provide a comprehensive survey of high-SBP imaging techniques, exploring their underlying principles and applications in bioimaging.

Full Text

Duke Authors

Cited Authors

  • Park, J; Brady, DJ; Zheng, G; Tian, L; Gao, L

Published Date

  • July 1, 2021

Published In

  • Advanced Photonics

Volume / Issue

  • 3 / 4

Electronic International Standard Serial Number (EISSN)

  • 2577-5421

Digital Object Identifier (DOI)

  • 10.1117/1.AP.3.4.044001

Citation Source

  • Scopus