We provide a commentary on the Parents Matter! intervention program. Our commentary is organized around core issues confronting those who design prevention programs, namely (1) making the program practical, feasible and economical, (2) reaching a broad base of target individuals, (3) making the intervention effective in changing the behavior or outcome for those who participate in it, and (4) ensuring that the intervention is sustainable for future generations. Parents Matter! is a thoughtful and impressive program that addresses each of these issues.