New Approaches to Glioblastoma.

Journal Article (Journal Article;Review)

Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly.

Full Text

Duke Authors

Cited Authors

  • Khasraw, M; Fujita, Y; Lee-Chang, C; Balyasnikova, IV; Najem, H; Heimberger, AB

Published Date

  • January 27, 2022

Published In

Volume / Issue

  • 73 /

Start / End Page

  • 279 - 292

PubMed ID

  • 34665646

Pubmed Central ID

  • PMC9479165

Electronic International Standard Serial Number (EISSN)

  • 1545-326X

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-042420-102102


  • eng

Conference Location

  • United States