Mapping the proteo-genomic convergence of human diseases.

Journal Article (Journal Article)

Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic associations for 3892 plasma proteins to create a cis-anchored gene-protein-disease map of 1859 connections that highlights strong cross-disease biological convergence. This proteo-genomic map provides a framework to connect etiologically related diseases, to provide biological context for new or emerging disorders, and to integrate different biological domains to establish mechanisms for known gene-disease links. Our results identify proteo-genomic connections within and between diseases and establish the value of cis-protein variants for annotation of likely causal disease genes at loci identified in genome-wide association studies, thereby addressing a major barrier to experimental validation and clinical translation of genetic discoveries.

Full Text

Duke Authors

Cited Authors

  • Pietzner, M; Wheeler, E; Carrasco-Zanini, J; Cortes, A; Koprulu, M; Wörheide, MA; Oerton, E; Cook, J; Stewart, ID; Kerrison, ND; Luan, J; Raffler, J; Arnold, M; Arlt, W; O'Rahilly, S; Kastenmüller, G; Gamazon, ER; Hingorani, AD; Scott, RA; Wareham, NJ; Langenberg, C

Published Date

  • November 12, 2021

Published In

Volume / Issue

  • 374 / 6569

Start / End Page

  • eabj1541 -

PubMed ID

  • 34648354

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.abj1541

Language

  • eng

Conference Location

  • United States