Indications for the Use of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Peptic Ulcer Bleeding in Hospitalized Patients.

Journal Article (Journal Article;Review)

Proton pump inhibitors are widely used throughout the world for the treatment of gastrointestinal disorders that are related to acid secretion, such as peptic ulcer disease and dyspepsia. Another common indication for proton pump inhibitors is stress ulcer prophylaxis. Proton pump inhibitors have proven efficacy for the treatment of acid-related gastrointestinal disorders, but there is concern that their use may be associated with the development of significant complications, such as fractures, Clostridium difficile infection, acute kidney injury, chronic kidney disease, and hypomagnesemia. Proton pump inhibitors are overused in the hospital setting, both for stress ulcer prophylaxis and gastrointestinal bleeding, and then they are often inappropriately continued after discharge from the hospital. This narrative review article outlines the evidence surrounding appropriate proton pump inhibitor use for stress ulcer prophylaxis and peptic ulcer bleeding.

Full Text

Duke Authors

Cited Authors

  • Clarke, K; Adler, N; Agrawal, D; Bhakta, D; Sata, SS; Singh, S; Gupta, A; Pahwa, A; Pherson, E; Sun, A; Volpicelli, F; Cho, HJ

Published Date

  • March 2022

Published In

Volume / Issue

  • 135 / 3

Start / End Page

  • 313 - 317

PubMed ID

  • 34655535

Electronic International Standard Serial Number (EISSN)

  • 1555-7162

Digital Object Identifier (DOI)

  • 10.1016/j.amjmed.2021.09.010


  • eng

Conference Location

  • United States