Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.

Journal Article (Journal Article)

We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.

Full Text

Duke Authors

Cited Authors

  • van der Laan, CM; Morosoli-García, JJ; van de Weijer, SGA; Colodro-Conde, L; ACTION Consortium, ; Lupton, MK; Mitchell, BL; McAloney, K; Parker, R; Burns, JM; Hickie, IB; Pool, R; Hottenga, J-J; Martin, NG; Medland, SE; Nivard, MG; Boomsma, DI

Published Date

  • September 2021

Published In

Volume / Issue

  • 51 / 5

Start / End Page

  • 592 - 606

PubMed ID

  • 34390460

Pubmed Central ID

  • PMC8390412

Electronic International Standard Serial Number (EISSN)

  • 1573-3297

Digital Object Identifier (DOI)

  • 10.1007/s10519-021-10076-6

Language

  • eng

Conference Location

  • United States