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Glioblastoma as an age-related neurological disorder in adults.

Publication ,  Journal Article
Kim, M; Ladomersky, E; Mozny, A; Kocherginsky, M; O'Shea, K; Reinstein, ZZ; Zhai, L; Bell, A; Lauing, KL; Bollu, L; Rabin, E; Dixit, K; Wu, J ...
Published in: Neurooncol Adv
2021

BACKGROUND: Advanced age is a major risk factor for the development of many diseases including those affecting the central nervous system. Wild-type isocitrate dehydrogenase glioblastoma (IDHwt GBM) is the most common primary malignant brain cancer and accounts for ≥90% of all adult GBM diagnoses. Patients with IDHwt GBM have a median age of diagnosis at 68-70 years of age, and increasing age is associated with an increasingly worse prognosis for patients with this type of GBM. METHODS: The Surveillance, Epidemiology, and End Results, The Cancer Genome Atlas, and the Chinese Glioma Genome Atlas databases were analyzed for mortality indices. Meta-analysis of 80 clinical trials was evaluated for log hazard ratio for aging to tumor survivorship. RESULTS: Despite significant advances in the understanding of intratumoral genetic alterations, molecular characteristics of tumor microenvironments, and relationships between tumor molecular characteristics and the use of targeted therapeutics, life expectancy for older adults with GBM has yet to improve. CONCLUSIONS: Based upon the results of our analysis, we propose that age-dependent factors that are yet to be fully elucidated, contribute to IDHwt GBM patient outcomes.

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Published In

Neurooncol Adv

DOI

EISSN

2632-2498

Publication Date

2021

Volume

3

Issue

1

Start / End Page

vdab125

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, M., Ladomersky, E., Mozny, A., Kocherginsky, M., O’Shea, K., Reinstein, Z. Z., … Wainwright, D. A. (2021). Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv, 3(1), vdab125. https://doi.org/10.1093/noajnl/vdab125
Kim, Miri, Erik Ladomersky, Andreas Mozny, Masha Kocherginsky, Kaitlyn O’Shea, Zachary Z. Reinstein, Lijie Zhai, et al. “Glioblastoma as an age-related neurological disorder in adults.Neurooncol Adv 3, no. 1 (2021): vdab125. https://doi.org/10.1093/noajnl/vdab125.
Kim M, Ladomersky E, Mozny A, Kocherginsky M, O’Shea K, Reinstein ZZ, et al. Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021;3(1):vdab125.
Kim, Miri, et al. “Glioblastoma as an age-related neurological disorder in adults.Neurooncol Adv, vol. 3, no. 1, 2021, p. vdab125. Pubmed, doi:10.1093/noajnl/vdab125.
Kim M, Ladomersky E, Mozny A, Kocherginsky M, O’Shea K, Reinstein ZZ, Zhai L, Bell A, Lauing KL, Bollu L, Rabin E, Dixit K, Kumthekar P, Platanias LC, Hou L, Zheng Y, Wu J, Zhang B, Hrachova M, Merrill SA, Mrugala MM, Prabhu VC, Horbinski C, James CD, Yamini B, Ostrom QT, Johnson MO, Reardon DA, Lukas RV, Wainwright DA. Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021;3(1):vdab125.

Published In

Neurooncol Adv

DOI

EISSN

2632-2498

Publication Date

2021

Volume

3

Issue

1

Start / End Page

vdab125

Location

England