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The Effects of Dexamethasone in Diabetic Patients Undergoing Primary Total Joint Arthroplasty.

Publication ,  Journal Article
Harding, MM; Xavier, SE; Seyler, TM; Ryan, SP
Published in: Orthop Nurs
September 2021

Dexamethasone reduces postoperative pain and nausea, with no evidence of increased rate of infection in total joint arthroplasty. However, the effects of dexamethasone on diabetic patients undergoing total joint arthroplasty remain relatively unexplored. The purpose of this study was to examine the effects of dexamethasone on postoperative blood glucose levels, prosthetic joint infections (PJIs), and 90-day hospital returns in diabetic patients following total joint arthroplasty. Retrospective analysis was performed on 228 adult patients with a diagnosis of diabetes who underwent primary total joint arthroplasty. Patients were stratified by intraoperative dexamethasone administration. In total, 173 (75.9%) patients received intraoperative dexamethasone, with no differences in demographic variables compared with patients who did not receive dexamethasone. There was no significant difference in PJIs or 90-day hospital returns. Patients who received dexamethasone had significantly increased blood glucose concentration on Postoperative Day 1 and were significantly more likely to have blood glucose levels exceeding 180 g/dl. Although postoperative blood glucose levels were significantly increased, it is unclear what effects, if any, transient hyperglycemia may have on outcomes. The outcomes of this study support perioperative administration of dexamethasone in diabetic patients.

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Published In

Orthop Nurs

DOI

EISSN

1542-538X

Publication Date

September 2021

Volume

40

Issue

5

Start / End Page

301 / 304

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Nursing
  • Humans
  • Diabetes Mellitus
  • Dexamethasone
  • Arthroplasty, Replacement, Knee
  • Arthroplasty, Replacement, Hip
  • Adult
  • 4205 Nursing
  • 1110 Nursing
 

Citation

APA
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Harding, M. M., Xavier, S. E., Seyler, T. M., & Ryan, S. P. (2021). The Effects of Dexamethasone in Diabetic Patients Undergoing Primary Total Joint Arthroplasty. Orthop Nurs, 40(5), 301–304. https://doi.org/10.1097/NOR.0000000000000790
Harding, Margaret M., Sonia E. Xavier, Thorsten M. Seyler, and Sean P. Ryan. “The Effects of Dexamethasone in Diabetic Patients Undergoing Primary Total Joint Arthroplasty.Orthop Nurs 40, no. 5 (September 2021): 301–4. https://doi.org/10.1097/NOR.0000000000000790.
Harding MM, Xavier SE, Seyler TM, Ryan SP. The Effects of Dexamethasone in Diabetic Patients Undergoing Primary Total Joint Arthroplasty. Orthop Nurs. 2021 Sep;40(5):301–4.
Harding, Margaret M., et al. “The Effects of Dexamethasone in Diabetic Patients Undergoing Primary Total Joint Arthroplasty.Orthop Nurs, vol. 40, no. 5, Sept. 2021, pp. 301–04. Pubmed, doi:10.1097/NOR.0000000000000790.
Harding MM, Xavier SE, Seyler TM, Ryan SP. The Effects of Dexamethasone in Diabetic Patients Undergoing Primary Total Joint Arthroplasty. Orthop Nurs. 2021 Sep;40(5):301–304.

Published In

Orthop Nurs

DOI

EISSN

1542-538X

Publication Date

September 2021

Volume

40

Issue

5

Start / End Page

301 / 304

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Nursing
  • Humans
  • Diabetes Mellitus
  • Dexamethasone
  • Arthroplasty, Replacement, Knee
  • Arthroplasty, Replacement, Hip
  • Adult
  • 4205 Nursing
  • 1110 Nursing