The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis.

Journal Article (Journal Article;Review)

Our understanding of sex differences in subclinical atherosclerosis and plaque composition and characteristics have greatly improved with the use of coronary computed tomography (CCTA) over the past years. CCTA has emerged as an important frontline diagnostic test for women, especially as we continue to understand the impact of non-obstructive atherosclerosis as well as diffuse, high risk plaque as precursors of acute cardiac events in women. Based on its ability to identify complex plaque morphology such as low attenuation plaque, high risk non calcified plaque, positive remodeling, fibrous cap, CCTA can be used to assess plaque characteristics. CCTA can avoid false positive of other imaging studies, if included earlier in assessment of ischemic symptoms. In the contemporary clinical setting, CCTA will prove useful in further understanding and managing cardiovascular disease in women and those without traditional obstructive coronary disease.

Full Text

Duke Authors

Cited Authors

  • Garg, K; Patel, TR; Kanwal, A; Villines, TC; Aggarwal, NR; Nasir, K; Blumenthal, RS; Blaha, MJ; Douglas, PS; Shaw, LJ; Sharma, G

Published Date

  • 2022

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 138 - 149

PubMed ID

  • 34654676

Pubmed Central ID

  • PMC9358989

Electronic International Standard Serial Number (EISSN)

  • 1876-861X

Digital Object Identifier (DOI)

  • 10.1016/j.jcct.2021.09.004


  • eng

Conference Location

  • United States