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Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging.

Publication ,  Journal Article
Niedbalski, PJ; Lu, J; Hall, CS; Castro, M; Mugler, JP; Shim, YM; Driehuys, B
Published in: Magn Reson Med
March 2022

PURPOSE: To reduce scan duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging by utilizing flip angle (FA)/TR equivalence. METHODS: Images were acquired in 12 subjects (n = 3 radiation therapy, n = 1 unexplained dyspnea, n = 8 healthy) using both standard (TR = 15 ms, FA = 20°, duration = 15 s, 998 projections) and "fast" (TR = 5.4 ms, FA = 12°, duration = 11.3 s, 2100 projections) acquisition parameters. For the fast acquisition, 3 image sets were reconstructed using subsets of 1900, 1500, and 1000 projections. From the resulting ventilation, tissue ("barrier"), and red blood cell (RBC) images, image metrics and biomarkers were compared to assess agreement between methods. RESULTS: Images acquired using both FA/TR settings had similar qualitative appearance. There were no significant differences in SNR, image mean, or image SD between images. Moreover, the percentage of the lungs in "defect", "normal", and "high" bins for each image (ventilation, RBC, barrier) was not significantly different among the acquisition types. After registration, comparison of 3D image metrics (Dice, volume similarity, average distance) agreed well between bins. Images using 1000 projections for reconstruction had no significant differences from images using all projections. CONCLUSION: Using flip angle/TR equivalence, hyperpolarized 129 Xe gas exchange images can be acquired via the 1-point Dixon technique in as little as 6 s, compared to ~15 s for previously reported parameter settings. The resulting images from this accelerated scan have no significant differences from the standard method in qualitative appearance or quantitative metrics.

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

March 2022

Volume

87

Issue

3

Start / End Page

1490 / 1499

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Imaging, Three-Dimensional
  • Humans
  • Breath Holding
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

APA
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ICMJE
MLA
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Niedbalski, P. J., Lu, J., Hall, C. S., Castro, M., Mugler, J. P., Shim, Y. M., & Driehuys, B. (2022). Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging. Magn Reson Med, 87(3), 1490–1499. https://doi.org/10.1002/mrm.29040
Niedbalski, Peter J., Junlan Lu, Chase S. Hall, Mario Castro, John P. Mugler, Yun M. Shim, and Bastiaan Driehuys. “Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging.Magn Reson Med 87, no. 3 (March 2022): 1490–99. https://doi.org/10.1002/mrm.29040.
Niedbalski PJ, Lu J, Hall CS, Castro M, Mugler JP, Shim YM, et al. Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging. Magn Reson Med. 2022 Mar;87(3):1490–9.
Niedbalski, Peter J., et al. “Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging.Magn Reson Med, vol. 87, no. 3, Mar. 2022, pp. 1490–99. Pubmed, doi:10.1002/mrm.29040.
Niedbalski PJ, Lu J, Hall CS, Castro M, Mugler JP, Shim YM, Driehuys B. Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging. Magn Reson Med. 2022 Mar;87(3):1490–1499.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

March 2022

Volume

87

Issue

3

Start / End Page

1490 / 1499

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Imaging, Three-Dimensional
  • Humans
  • Breath Holding
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering