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Global Respiratory Syncytial Virus-Related Infant Community Deaths.

Publication ,  Journal Article
Mazur, NI; Löwensteyn, YN; Willemsen, JE; Gill, CJ; Forman, L; Mwananyanda, LM; Blau, DM; Breiman, RF; Madhi, SA; Mahtab, S; Gurley, ES ...
Published in: Clin Infect Dis
September 2, 2021

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. METHODS: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. RESULTS: We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). CONCLUSIONS: We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.

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Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

September 2, 2021

Volume

73

Issue

Suppl_3

Start / End Page

S229 / S237

Location

United States

Related Subject Headings

  • Respiratory Syncytial Virus, Human
  • Respiratory Syncytial Virus Vaccines
  • Respiratory Syncytial Virus Infections
  • Microbiology
  • Infant, Newborn
  • Infant Death
  • Infant
  • Humans
  • Hospitalization
  • Child
 

Citation

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Mazur, N. I., Löwensteyn, Y. N., Willemsen, J. E., Gill, C. J., Forman, L., Mwananyanda, L. M., … Bont, L. J. (2021). Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis, 73(Suppl_3), S229–S237. https://doi.org/10.1093/cid/ciab528
Mazur, Natalie I., Yvette N. Löwensteyn, Joukje E. Willemsen, Christopher J. Gill, Leah Forman, Lawrence M. Mwananyanda, Dianna M. Blau, et al. “Global Respiratory Syncytial Virus-Related Infant Community Deaths.Clin Infect Dis 73, no. Suppl_3 (September 2, 2021): S229–37. https://doi.org/10.1093/cid/ciab528.
Mazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, et al. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229–37.
Mazur, Natalie I., et al. “Global Respiratory Syncytial Virus-Related Infant Community Deaths.Clin Infect Dis, vol. 73, no. Suppl_3, Sept. 2021, pp. S229–37. Pubmed, doi:10.1093/cid/ciab528.
Mazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, Blau DM, Breiman RF, Madhi SA, Mahtab S, Gurley ES, El Arifeen S, Assefa N, Scott JAG, Onyango D, Tippet Barr BA, Kotloff KL, Sow SO, Mandomando I, Ogbuanu I, Jambai A, Bassat Q, CHAMPS Network the RSV GOLD Study Group, Caballero MT, Polack FP, Omer S, Kazi AM, Simões EAF, Satav A, Bont LJ. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229–S237.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

September 2, 2021

Volume

73

Issue

Suppl_3

Start / End Page

S229 / S237

Location

United States

Related Subject Headings

  • Respiratory Syncytial Virus, Human
  • Respiratory Syncytial Virus Vaccines
  • Respiratory Syncytial Virus Infections
  • Microbiology
  • Infant, Newborn
  • Infant Death
  • Infant
  • Humans
  • Hospitalization
  • Child