Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells.

Journal Article (Journal Article)

The neocortex comprises multiple information processing streams mediated by subsets of glutamatergic pyramidal cells (PCs) that receive diverse inputs and project to distinct targets. How GABAergic interneurons regulate the segregation and communication among intermingled PC subsets that contribute to separate brain networks remains unclear. Here we demonstrate that a subset of GABAergic chandelier cells (ChCs) in the prelimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to the basolateral amygdala (BLAPC) compared to those projecting to contralateral cortex (CCPC). These ChCs in turn receive preferential input from local and contralateral CCPCs as opposed to BLAPCs and BLA neurons (the prelimbic cortex-BLA network). Accordingly, optogenetic activation of ChCs rapidly suppresses BLAPCs and BLA activity in freely behaving mice. Thus, the exquisite connectivity of ChCs not only mediates directional inhibition between local PC ensembles but may also shape communication hierarchies between global networks.

Full Text

Duke Authors

Cited Authors

  • Lu, J; Tucciarone, J; Padilla-Coreano, N; He, M; Gordon, JA; Huang, ZJ

Published Date

  • October 2017

Published In

Volume / Issue

  • 20 / 10

Start / End Page

  • 1377 - 1383

PubMed ID

  • 28825718

Pubmed Central ID

  • PMC5614838

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.4624

Language

  • eng

Conference Location

  • United States