A neural circuit for spatial summation in visual cortex.

Journal Article (Journal Article)

The response of cortical neurons to a sensory stimulus is modulated by the context. In the visual cortex, for example, stimulation of a pyramidal cell's receptive-field surround can attenuate the cell's response to a stimulus in the centre of its receptive field, a phenomenon called surround suppression. Whether cortical circuits contribute to surround suppression or whether the phenomenon is entirely relayed from earlier stages of visual processing is debated. Here we show that, in contrast to pyramidal cells, the response of somatostatin-expressing inhibitory neurons (SOMs) in the superficial layers of the mouse visual cortex increases with stimulation of the receptive-field surround. This difference results from the preferential excitation of SOMs by horizontal cortical axons. By perturbing the activity of SOMs, we show that these neurons contribute to pyramidal cells' surround suppression. These results establish a cortical circuit for surround suppression and attribute a particular function to a genetically defined type of inhibitory neuron.

Full Text

Duke Authors

Cited Authors

  • Adesnik, H; Bruns, W; Taniguchi, H; Huang, ZJ; Scanziani, M

Published Date

  • October 11, 2012

Published In

Volume / Issue

  • 490 / 7419

Start / End Page

  • 226 - 231

PubMed ID

  • 23060193

Pubmed Central ID

  • PMC3621107

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

Digital Object Identifier (DOI)

  • 10.1038/nature11526

Language

  • eng

Conference Location

  • England