Experience-dependent modification of a central amygdala fear circuit.

Journal Article (Journal Article)

The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of fear is unclear. We found that fear conditioning in mice induced robust plasticity of excitatory synapses onto inhibitory neurons in the lateral subdivision of the CeA (CeL). This experience-dependent plasticity was cell specific, bidirectional and expressed presynaptically by inputs from the lateral amygdala. In particular, preventing synaptic potentiation onto somatostatin-positive neurons impaired fear memory formation. Furthermore, activation of these neurons was necessary for fear memory recall and was sufficient to drive fear responses. Our findings support a model in which fear conditioning-induced synaptic modifications in CeL favor the activation of somatostatin-positive neurons, which inhibit CeL output, thereby disinhibiting the medial subdivision of CeA and releasing fear expression.

Full Text

Duke Authors

Cited Authors

  • Li, H; Penzo, MA; Taniguchi, H; Kopec, CD; Huang, ZJ; Li, B

Published Date

  • March 2013

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 332 - 339

PubMed ID

  • 23354330

Pubmed Central ID

  • PMC3581751

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.3322

Language

  • eng

Conference Location

  • United States