Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.
Journal Article (Journal Article)
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.
Full Text
Duke Authors
Cited Authors
- Di Cristo, G; Wu, C; Chattopadhyaya, B; Ango, F; Knott, G; Welker, E; Svoboda, K; Huang, ZJ
Published Date
- November 2004
Published In
Volume / Issue
- 7 / 11
Start / End Page
- 1184 - 1186
PubMed ID
- 15475951
International Standard Serial Number (ISSN)
- 1097-6256
Digital Object Identifier (DOI)
- 10.1038/nn1334
Language
- eng
Conference Location
- United States