Long-term antithrombotic therapy after venous stent placement

Journal Article

Objectives To examine the prescribing patterns and outcomes of antithrombotic regimens after venous stent placement. Methods A total of 87 patients who received inferior vena cava or iliofemoral venous stents were included in the study. A retrospective review was performed to determine the antithrombotic regimens and the subsequent rates of in-stent restenosis, stent thrombosis, and bleeding. Results The prescribing patterns of specific antithrombotic regimens were highly variable. In-stent restenosis and stent thrombosis events were observed in 13 of 63 patients (21%) with available follow-up imaging, while major bleeding events were noted in 6 of 87 patients (7%). Triple therapy appeared to reduce the odds of in-stent restenosis/ stent thrombosis when compared to dual antiplatelet therapy (OR = 0.07, P = 0.01). Conclusions Substantial variability exists in antithrombotic therapy following venous stenting at our institution. This study demonstrated a reduction of in-stent restenosis/thrombosis events when utilizing triple therapy compared to antiplatelet-only regimens. However, larger prospective trials are needed to more accurately determine the relative risks and benefits of each antithrombotic regimen.

Full Text

Duke Authors

Cited Authors

  • Lin, C; Martin, KA; Wang, M; Stein, BL; Desai, KR

Published Date

  • July 2020

Published In

Volume / Issue

  • 35 / 6

Start / End Page

  • 402 - 408

Published By

Electronic International Standard Serial Number (EISSN)

  • 1758-1125

International Standard Serial Number (ISSN)

  • 0268-3555

Digital Object Identifier (DOI)

  • 10.1177/0268355519893819


  • en