A primer on metabolic memory: Why existing diabesity treatments fail
Publication
, Journal Article
Copur, S; Rossing, P; Afsar, B; Sag, AA; Siriopol, D; Kuwabara, M; Ortiz, A; Kanbay, M
Published in: Clinical Kidney Journal
March 1, 2021
Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.
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Published In
Clinical Kidney Journal
DOI
EISSN
2048-8513
ISSN
2048-8505
Publication Date
March 1, 2021
Volume
14
Issue
3
Start / End Page
756 / 767
Related Subject Headings
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Copur, S., Rossing, P., Afsar, B., Sag, A. A., Siriopol, D., Kuwabara, M., … Kanbay, M. (2021). A primer on metabolic memory: Why existing diabesity treatments fail. Clinical Kidney Journal, 14(3), 756–767. https://doi.org/10.1093/ckj/sfaa143
Copur, S., P. Rossing, B. Afsar, A. A. Sag, D. Siriopol, M. Kuwabara, A. Ortiz, and M. Kanbay. “A primer on metabolic memory: Why existing diabesity treatments fail.” Clinical Kidney Journal 14, no. 3 (March 1, 2021): 756–67. https://doi.org/10.1093/ckj/sfaa143.
Copur S, Rossing P, Afsar B, Sag AA, Siriopol D, Kuwabara M, et al. A primer on metabolic memory: Why existing diabesity treatments fail. Clinical Kidney Journal. 2021 Mar 1;14(3):756–67.
Copur, S., et al. “A primer on metabolic memory: Why existing diabesity treatments fail.” Clinical Kidney Journal, vol. 14, no. 3, Mar. 2021, pp. 756–67. Scopus, doi:10.1093/ckj/sfaa143.
Copur S, Rossing P, Afsar B, Sag AA, Siriopol D, Kuwabara M, Ortiz A, Kanbay M. A primer on metabolic memory: Why existing diabesity treatments fail. Clinical Kidney Journal. 2021 Mar 1;14(3):756–767.
Published In
Clinical Kidney Journal
DOI
EISSN
2048-8513
ISSN
2048-8505
Publication Date
March 1, 2021
Volume
14
Issue
3
Start / End Page
756 / 767
Related Subject Headings
- 3202 Clinical sciences