A primer on metabolic memory: Why existing diabesity treatments fail

Journal Article (Review;Journal)

Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.

Full Text

Duke Authors

Cited Authors

  • Copur, S; Rossing, P; Afsar, B; Sag, AA; Siriopol, D; Kuwabara, M; Ortiz, A; Kanbay, M

Published Date

  • March 1, 2021

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 756 - 767

Electronic International Standard Serial Number (EISSN)

  • 2048-8513

International Standard Serial Number (ISSN)

  • 2048-8505

Digital Object Identifier (DOI)

  • 10.1093/ckj/sfaa143

Citation Source

  • Scopus