Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.
Publication
, Journal Article
Mu, Z; Haynes, BF; Cain, DW
Published in: Curr Opin Virol
December 2021
A prophylactic vaccine would be a powerful tool in the fight against HIV. Passive immunization of animals with broadly neutralizing antibodies (bnAbs) affords protection against viral challenge, and recent data from the Antibody Mediated Prevention clinical trials support the concept of bnAbs providing protection against HIV in humans, albeit only at broad and potent neutralizing antibody titers. Moreover, it is now clear that a successful vaccine will also need to induce bnAbs against multiple neutralizing epitopes on the HIV envelope (Env) glycoprotein. Here, we review recent clinical trials evaluating bnAb-based vaccines, and discuss key issues in the development of an HIV vaccine capable of targeting multiple Env neutralizing epitopes.
Duke Scholars
Published In
Curr Opin Virol
DOI
EISSN
1879-6265
Publication Date
December 2021
Volume
51
Start / End Page
172 / 178
Location
Netherlands
Related Subject Headings
- Vaccination
- Humans
- HIV Infections
- HIV Antibodies
- HIV
- Epitopes
- Broadly Neutralizing Antibodies
- Animals
- AIDS Vaccines
- 3107 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Mu, Z., Haynes, B. F., & Cain, D. W. (2021). Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination. Curr Opin Virol, 51, 172–178. https://doi.org/10.1016/j.coviro.2021.09.015
Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.” Curr Opin Virol 51 (December 2021): 172–78. https://doi.org/10.1016/j.coviro.2021.09.015.
Mu Z, Haynes BF, Cain DW. Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination. Curr Opin Virol. 2021 Dec;51:172–8.
Mu, Zekun, et al. “Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.” Curr Opin Virol, vol. 51, Dec. 2021, pp. 172–78. Pubmed, doi:10.1016/j.coviro.2021.09.015.
Mu Z, Haynes BF, Cain DW. Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination. Curr Opin Virol. 2021 Dec;51:172–178.
Published In
Curr Opin Virol
DOI
EISSN
1879-6265
Publication Date
December 2021
Volume
51
Start / End Page
172 / 178
Location
Netherlands
Related Subject Headings
- Vaccination
- Humans
- HIV Infections
- HIV Antibodies
- HIV
- Epitopes
- Broadly Neutralizing Antibodies
- Animals
- AIDS Vaccines
- 3107 Microbiology