Racial-ethnic differences in health-related quality of life among adults and children with glomerular disease.
Journal Article (Journal Article)
INTRODUCTION: Disparities in health-related quality of life (HRQOL) have been inadequately studied in patients with glomerular disease. The aim of this study was to identify relationships between race/ethnicity, socioeconomic status, disease severity, and HRQOL in an ethnically and racially diverse cohort of patients with glomerular disease. METHODS: Cure Glomerulonephropathy (CureGN) is a multinational cohort study of patients with biopsy-proven glomerular disease. Associations between race/ethnicity and HRQOL were determined by the following: 1. Missed school or work due to kidney disease; 2. Responses to Patient Reported Outcomes Measurement Information System (PROMIS) questionnaires. We adjusted for demographics, socioeconomic status, and disease characteristics using multivariable logistic and linear regression. RESULTS: Black and Hispanic participants had worse socioeconomic status and more severe glomerular disease than White or Asian participants. Black adults missed work or school most frequently due to kidney disease (30% versus 16-23% in the other three groups, p=0.04), and had the worst self-reported global physical health (median score 44.1 versus 48.0-48.2, p<0.001) and fatigue (53.8 versus 48.5-51.1, p=0.002), compared to other racial/ethnic groups. However, these findings were not statistically significant with adjustment for socioeconomic status and disease severity, both of which were strongly associated with HRQOL in adults. Among children, disease severity but not race/ethnicity or socioeconomic status were associated with HRQOL. CONCLUSIONS: Among patients with glomerular disease enrolled in CureGN, the worse HRQOL reported by Black adults was attributable to lower socioeconomic status and more severe glomerular disease. No racial/ethnic differences in HRQOL were observed in children.
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Duke Authors
Cited Authors
- Krissberg, JR; Helmuth, ME; Almaani, S; Cai, Y; Cattran, D; Chatterjee, D; Gbadegesin, RA; Gibson, KL; Glenn, DA; Greenbaum, LA; Iragorri, S; Jain, K; Khalid, M; Kidd, JM; Kopp, JB; Lafayette, R; Nestor, JG; Parekh, RS; Reidy, KJ; David T Selewski, ; John Sperati, C; Tuttle, KR; Twombley, K; Vasylyeva, TL; Weaver, DJ; Wenderfer, SE; O'Shaughnessy, MM
Published Date
- August 2021
Published In
Volume / Issue
- 1 / 3
Start / End Page
- 105 - 117
PubMed ID
- 34723246
Pubmed Central ID
- PMC8553235
Electronic International Standard Serial Number (EISSN)
- 2673-3633
Digital Object Identifier (DOI)
- 10.1159/000516832
Language
- eng
Conference Location
- Switzerland