Skip to main content
Journal cover image

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Publication ,  Journal Article
Cade, BE; Lee, J; Sofer, T; Wang, H; Zhang, M; Chen, H; Gharib, SA; Gottlieb, DJ; Guo, X; Lane, JM; Liang, J; Lin, X; Mei, H; Patel, SR ...
Published in: Genome Med
August 26, 2021

BACKGROUND: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. METHODS: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturation < 90%. We adjusted for age, sex, BMI, study, and family structure using MMSKAT and EMMAX mixed linear model approaches. Additional bioinformatics analyses were performed with MetaXcan, GIGSEA, and ReMap. RESULTS: We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10-8) on chromosome X with ARMCX3. Additional rare-variant associations include ARMCX3-AS1, MRPS33, and C16orf90. Novel common-variant loci were identified in the NRG1 and SLC45A2 regions, and previously associated loci in the IL18RAP and ATP2B4 regions were associated with novel phenotypes. Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Additional analyses identified significantly associated pathways. CONCLUSIONS: We have identified the first gene-based rare-variant associations with objectively measured sleep-disordered breathing traits. Our results increase the understanding of the genetic architecture of sleep-disordered breathing and highlight associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis, and HIF1A-mediated hypoxic response.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Genome Med

DOI

EISSN

1756-994X

Publication Date

August 26, 2021

Volume

13

Issue

1

Start / End Page

136

Location

England

Related Subject Headings

  • Whole Genome Sequencing
  • United States
  • Sleep Apnea Syndromes
  • Signal Transduction
  • Research
  • Precision Medicine
  • Phenotype
  • National Heart, Lung, and Blood Institute (U.S.)
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cade, B. E., Lee, J., Sofer, T., Wang, H., Zhang, M., Chen, H., … TOPMed Sleep Working Group, . (2021). Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med, 13(1), 136. https://doi.org/10.1186/s13073-021-00917-8
Cade, Brian E., Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A. Gharib, et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.Genome Med 13, no. 1 (August 26, 2021): 136. https://doi.org/10.1186/s13073-021-00917-8.
Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, et al. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med. 2021 Aug 26;13(1):136.
Cade, Brian E., et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.Genome Med, vol. 13, no. 1, Aug. 2021, p. 136. Pubmed, doi:10.1186/s13073-021-00917-8.
Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, Redline S, TOPMed Sleep Working Group. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med. 2021 Aug 26;13(1):136.
Journal cover image

Published In

Genome Med

DOI

EISSN

1756-994X

Publication Date

August 26, 2021

Volume

13

Issue

1

Start / End Page

136

Location

England

Related Subject Headings

  • Whole Genome Sequencing
  • United States
  • Sleep Apnea Syndromes
  • Signal Transduction
  • Research
  • Precision Medicine
  • Phenotype
  • National Heart, Lung, and Blood Institute (U.S.)
  • Male
  • Humans