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Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors.

Publication ,  Journal Article
Steiger, C; Phan, NV; Huang, H-W; Sun, H; Chu, JN; Reker, D; Gwynne, D; Collins, J; Tamang, S; McManus, R; Lopes, A; Hayward, A; Baron, RM ...
Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
December 2021

Continuous monitoring in the intensive care setting has transformed the capacity to rapidly respond with interventions for patients in extremis. Noninvasive monitoring has generally been limited to transdermal or intravascular systems coupled to transducers including oxygen saturation or pressure. Here it is hypothesized that gastric fluid (GF) and gases, accessible through nasogastric (NG) tubes, commonly found in intensive care settings, can provide continuous access to a broad range of biomarkers. A broad characterization of biomarkers in swine GF coupled to time-matched serum is conducted . The relationship and kinetics of GF-derived analyte level dynamics is established by correlating these to serum levels in an acute renal failure and an inducible stress model performed in swine. The ability to monitor ketone levels and an inhaled anaesthetic agent (isoflurane) in vivo is demonstrated with novel NG-compatible sensor systems in swine. Gastric access remains a main stay in the care of the critically ill patient, and here the potential is established to harness this establishes route for analyte evaluation for clinical management.

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Published In

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DOI

EISSN

2198-3844

ISSN

2198-3844

Publication Date

December 2021

Volume

8

Issue

24

Start / End Page

e2102861

Related Subject Headings

  • Swine
  • Stomach
  • Monitoring, Physiologic
  • Ketones
  • Isoflurane
  • Intubation, Gastrointestinal
  • Gastric Juice
  • Disease Models, Animal
  • Biomarkers
  • Animals
 

Citation

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Steiger, C., Phan, N. V., Huang, H.-W., Sun, H., Chu, J. N., Reker, D., … Traverso, G. (2021). Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), 8(24), e2102861. https://doi.org/10.1002/advs.202102861
Steiger, Christoph, Nhi V. Phan, Hen-Wei Huang, Haoying Sun, Jacqueline N. Chu, Daniel Reker, Declan Gwynne, et al. “Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors.Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 8, no. 24 (December 2021): e2102861. https://doi.org/10.1002/advs.202102861.
Steiger C, Phan NV, Huang H-W, Sun H, Chu JN, Reker D, et al. Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021 Dec;8(24):e2102861.
Steiger, Christoph, et al. “Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors.Advanced Science (Weinheim, Baden-Wurttemberg, Germany), vol. 8, no. 24, Dec. 2021, p. e2102861. Epmc, doi:10.1002/advs.202102861.
Steiger C, Phan NV, Huang H-W, Sun H, Chu JN, Reker D, Gwynne D, Collins J, Tamang S, McManus R, Lopes A, Hayward A, Baron RM, Kim EY, Traverso G. Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021 Dec;8(24):e2102861.
Journal cover image

Published In

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DOI

EISSN

2198-3844

ISSN

2198-3844

Publication Date

December 2021

Volume

8

Issue

24

Start / End Page

e2102861

Related Subject Headings

  • Swine
  • Stomach
  • Monitoring, Physiologic
  • Ketones
  • Isoflurane
  • Intubation, Gastrointestinal
  • Gastric Juice
  • Disease Models, Animal
  • Biomarkers
  • Animals