Hormonal contraceptive use before and after conception in relation to preterm birth and small for gestational age: an observational cohort study.

Journal Article (Journal Article)

OBJECTIVE: To evaluate whether hormonal contraceptives, used before or in early pregnancy, confer increased risk of preterm birth or reduced fetal growth. DESIGN: Population-based cohort study conducted by the Norwegian Institute of Public Health (Mother and Child Cohort Study, 1998-2008) with linkage to the Norwegian Prescription Registry and to the Medical Birth Registry of Norway. SETTING: Norway. POPULATION: Of the 48,615 pregnancies meeting study inclusion criteria, 44,734 pregnancies were included in the complete case analysis. METHODS: We characterised hormonal contraception by type (combination oral, progestin-only oral, vaginal ring, transdermal, and injectable) and specific progestin component. We used generalised estimating equations to estimate the odds of adverse outcome according to formulation used. Several sensitivity analyses were conducted. MAIN OUTCOME MEASURES: Preterm birth, small for gestational age. RESULTS: We observed a positive association between use of a combination oral contraceptive and preterm birth for all exposure periods (e.g. adjusted odds ratio 1.21, 95% confidence interval 1.04-1.41 for last use 12 to >4 months before conception); combination contraceptives containing the progestin norethisterone were consistently related to risk. Other types of hormonal contraception were generally not associated with preterm birth; none were related to small for gestational age. Observed associations were robust to sensitivity analyses. CONCLUSION: Hormonally active agents may exert dose-, agent-, and timing-specific effects on growth and development. We found that the particular progestin component is important when assessing the potential for adverse effects among former users of hormonal contraceptives.

Full Text

Duke Authors

Cited Authors

  • Jensen, ET; Daniels, JL; Stürmer, T; Robinson, WR; Williams, CJ; Vejrup, K; Magnus, P; Longnecker, MP

Published Date

  • September 2015

Published In

Volume / Issue

  • 122 / 10

Start / End Page

  • 1349 - 1361

PubMed ID

  • 25318662

Pubmed Central ID

  • PMC4400183

Electronic International Standard Serial Number (EISSN)

  • 1471-0528

Digital Object Identifier (DOI)

  • 10.1111/1471-0528.13114


  • eng

Conference Location

  • England