Maternal hormonal contraceptive use and offspring overweight or obesity.

Journal Article (Journal Article)

BACKGROUND/OBJECTIVES: Experiments in animal models have shown a positive association between in utero exposure to pharmacologic sex hormones and offspring obesity. The developmental effects of such hormones on human obesity are unknown. SUBJECTS/METHODS: Using data from a large, prospective pregnancy cohort study (n=19 652), with linkage to a national prescription registry, we evaluated the association between use of hormonal contraceptives before and after conception (defined from dispensed prescription data and characterized by last date of use relative to conception, 12 to >4 months before (n=3392), 4 to >1 months before (n=2541), 1 to >0 months before (n=2997) and 0-12 weeks after (n=567)) in relation to offspring overweight or obesity at age 3 years. RESULTS: We observed a weak, inverse association between early pregnancy use of a combination oral contraceptive and offspring overweight or obesity at age 3 (adjusted odds ratio (OR): 0.75, 95% confidence interval (CI): 0.53, 1.08) and a positive, but imprecise, association with use of a progestin-only oral contraceptive in early pregnancy (adjusted OR: 1.26, 95% CI: 0.79, 2.02). In general, no association was observed between the use of a hormonal contraceptive before conception and offspring overweight or obesity. A sensitivity analysis comparing combination oral contraceptive users in early pregnancy to other unplanned pregnancies without hormonal contraceptive use further strengthened the inverse association (adjusted OR: 0.70, 95% CI: 0.48, 1.02). Other sensitivity analyses were conducted to evaluate the robustness of the associations observed given varying assumptions. CONCLUSIONS: Pharmacologic sex hormones in early pregnancy may be inversely or positively associated with offspring overweight or obesity at age 3, depending on the specific formulation used. The present study provides support for the potential for environmental sources of hormonally active agents to exert developmental effects.

Full Text

Duke Authors

Cited Authors

  • Jensen, ET; Daniels, JL; Stürmer, T; Robinson, WR; Williams, CJ; Moster, D; Juliusson, PB; Vejrup, K; Magnus, P; Longnecker, MP

Published Date

  • October 2014

Published In

Volume / Issue

  • 38 / 10

Start / End Page

  • 1275 - 1281

PubMed ID

  • 24984751

Pubmed Central ID

  • PMC4365991

Electronic International Standard Serial Number (EISSN)

  • 1476-5497

Digital Object Identifier (DOI)

  • 10.1038/ijo.2014.114


  • eng

Conference Location

  • England