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Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.

Publication ,  Journal Article
Bush, MA; Anstey, NM; Yeo, TW; Florence, SM; Granger, DL; Mwaikambo, ED; Weinberg, JB
Published in: Front Cell Dev Biol
2021

Malaria caused by Plasmodium falciparum results in over 400,000 deaths annually, predominantly affecting African children. In addition, non-falciparum species including vivax and knowlesi cause significant morbidity and mortality. Vascular dysfunction is a key feature in malaria pathogenesis leading to impaired blood perfusion, vascular obstruction, and tissue hypoxia. Contributing factors include adhesion of infected RBC to endothelium, endothelial activation, and reduced nitric oxide formation. Endothelial glycocalyx (eGC) protects the vasculature by maintaining vessel integrity and regulating cellular adhesion and nitric oxide signaling pathways. Breakdown of eGC is known to occur in infectious diseases such as bacterial sepsis and dengue and is associated with adverse outcomes. Emerging studies using biochemical markers and in vivo imaging suggest that eGC breakdown occurs during Plasmodium infection and is associated with markers of malaria disease severity, endothelial activation, and vascular function. In this review, we describe characteristics of eGC breakdown in malaria and discuss how these relate to vascular dysfunction and adverse outcomes. Further understanding of this process may lead to adjunctive therapy to preserve or restore damaged eGC and reduce microvascular dysfunction and the morbidity/mortality of malaria.

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Published In

Front Cell Dev Biol

DOI

ISSN

2296-634X

Publication Date

2021

Volume

9

Start / End Page

751251

Location

Switzerland

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

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Bush, M. A., Anstey, N. M., Yeo, T. W., Florence, S. M., Granger, D. L., Mwaikambo, E. D., & Weinberg, J. B. (2021). Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx. Front Cell Dev Biol, 9, 751251. https://doi.org/10.3389/fcell.2021.751251
Bush, Margaret A., Nicholas M. Anstey, Tsin W. Yeo, Salvatore M. Florence, Donald L. Granger, Esther D. Mwaikambo, and J Brice Weinberg. “Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.Front Cell Dev Biol 9 (2021): 751251. https://doi.org/10.3389/fcell.2021.751251.
Bush MA, Anstey NM, Yeo TW, Florence SM, Granger DL, Mwaikambo ED, et al. Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx. Front Cell Dev Biol. 2021;9:751251.
Bush, Margaret A., et al. “Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.Front Cell Dev Biol, vol. 9, 2021, p. 751251. Pubmed, doi:10.3389/fcell.2021.751251.
Bush MA, Anstey NM, Yeo TW, Florence SM, Granger DL, Mwaikambo ED, Weinberg JB. Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx. Front Cell Dev Biol. 2021;9:751251.

Published In

Front Cell Dev Biol

DOI

ISSN

2296-634X

Publication Date

2021

Volume

9

Start / End Page

751251

Location

Switzerland

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 31 Biological sciences