Longevity and stress in Caenorhabditis elegans.

Journal Article (Review;Journal Article)

It has long been understood that many of the same manipulations that increase longevity in Caenorhabditis elegans also increase resistance to various acute stressors, and vice-versa; moreover these findings hold in more complex organisms as well. Nevertheless, the mechanistic relationship between these phenotypes remains unclear, and in many cases the overlap between stress resistance and longevity is inexact. Here we review the known connections between stress resistance and longevity, discuss instances in which these connections are absent, and summarize the theoretical explanations that have been posited for these phenomena.

Full Text

Duke Authors

Cited Authors

  • Zhou, KI; Pincus, Z; Slack, FJ

Published Date

  • August 2011

Published In

Volume / Issue

  • 3 / 8

Start / End Page

  • 733 - 753

PubMed ID

  • 21937765

Pubmed Central ID

  • PMC3184976

Electronic International Standard Serial Number (EISSN)

  • 1945-4589

International Standard Serial Number (ISSN)

  • 1945-4589

Digital Object Identifier (DOI)

  • 10.18632/aging.100367

Language

  • eng