MicroRNAs both promote and antagonize longevity in C. elegans.

Journal Article (Journal Article)

Background

aging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span.

Results

here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most upregulated miRNAs lead to life-span defects. Some act to promote normal life span and stress resistance, whereas others inhibit these phenomena. We find that these miRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin signaling pathway.

Conclusions

our findings reveal that miRNAs both positively and negatively influence life span. Because several miRNAs upregulated during aging regulate genes in conserved pathways of aging and thereby influence life span in C. elegans, we propose that miRNAs may play important roles in stress response and aging of more complex organisms.

Full Text

Duke Authors

Cited Authors

  • de Lencastre, A; Pincus, Z; Zhou, K; Kato, M; Lee, SS; Slack, FJ

Published Date

  • December 2, 2010

Published In

Volume / Issue

  • 20 / 24

Start / End Page

  • 2159 - 2168

PubMed ID

  • 21129974

Pubmed Central ID

  • PMC3023310

Electronic International Standard Serial Number (EISSN)

  • 1879-0445

International Standard Serial Number (ISSN)

  • 0960-9822

Digital Object Identifier (DOI)

  • 10.1016/j.cub.2010.11.015

Language

  • eng