Toward improved accuracy in shear wave elastography of arteries through controlling the arterial response to ultrasound perturbation in-silico and in phantoms.

Journal Article (Journal Article)

Dispersion-based inversion has been proposed as a viable direction for materials characterization of arteries, allowing clinicians to better study cardiovascular conditions using shear wave elastography. However, these methods rely ona prioriknowledge of the vibrational modes dominating the propagating waves induced by acoustic radiation force excitation: differences between anticipated and real modal content are known to yield errors in the inversion. We seek to improve the accuracy of this process by modeling the artery as a fluid-immersed cylindrical waveguide and building an analytical framework to prescribe radiation force excitations that will selectively excite certain waveguide modes using ultrasound acoustic radiation force. We show that all even-numbered waveguide modes can be eliminated from the arterial response to perturbation, and confirm the efficacy of this approach within silicotests that show that odd modes are preferentially excited. Finally, by analyzing data from phantom tests, we find a set of ultrasound focal parameters that demonstrate the viability of inducing the desired odd-mode response in experiments.

Full Text

Duke Authors

Cited Authors

  • Hugenberg, NR; Roy, T; Harrigan, H; Capriotti, M; Lee, H-K; Guddati, M; Greenleaf, JF; Urban, MW; Aquino, W

Published Date

  • November 26, 2021

Published In

Volume / Issue

  • 66 / 23

PubMed ID

  • 34763319

Pubmed Central ID

  • PMC8787730

Electronic International Standard Serial Number (EISSN)

  • 1361-6560

International Standard Serial Number (ISSN)

  • 0031-9155

Digital Object Identifier (DOI)

  • 10.1088/1361-6560/ac38fe

Language

  • eng