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Innovations in Heart Transplantation: A Review.

Publication ,  Journal Article
Coniglio, AC; Patel, CB; Kittleson, M; Schlendorf, K; Schroder, JN; DeVore, AD
Published in: J Card Fail
March 2022

Advanced heart failure affects tens of thousands of people in the United States alone with high morbidity and mortality. Cardiac transplantation offers the best treatment strategy, but has been limited historically by donor availability. Recently, there have been significant advances in organ allocation, donor-recipient matching, organ preservation, and expansion of the donor pool. The current heart allocation system prioritizes the sickest patients to minimize waitlist mortality. Advances in donor organ selection, including predicted heart mass calculations and more sophisticated antibody detection methods for allosensitized patients, offer more effective matching of donors and recipients. Innovations in organ preservation such as with organ preservation systems have widened the donor pool geographically. The use of donors with hepatitis C is possible with the advent of effective direct-acting antiviral agents to cure donor-transmitted hepatitis C. Finally, further expansion of the donor pool is occurring with the use of higher risk donors with advanced age, medical comorbidities, and left ventricular dysfunction and advances in donation after circulatory death. This review provides an update on the new technologies and transplantation strategies that serve to widen the donor pool and more effectively match donors and recipients so that heart transplant candidates may derive the best outcomes from heart transplantation.

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Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

March 2022

Volume

28

Issue

3

Start / End Page

467 / 476

Location

United States

Related Subject Headings

  • United States
  • Tissue and Organ Procurement
  • Tissue Donors
  • Humans
  • Hepatitis C, Chronic
  • Hepatitis C
  • Heart Transplantation
  • Heart Failure
  • Cardiovascular System & Hematology
  • Antiviral Agents
 

Citation

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Coniglio, A. C., Patel, C. B., Kittleson, M., Schlendorf, K., Schroder, J. N., & DeVore, A. D. (2022). Innovations in Heart Transplantation: A Review. J Card Fail, 28(3), 467–476. https://doi.org/10.1016/j.cardfail.2021.10.011
Coniglio, Amanda C., Chetan B. Patel, Michelle Kittleson, Kelly Schlendorf, Jacob N. Schroder, and Adam D. DeVore. “Innovations in Heart Transplantation: A Review.J Card Fail 28, no. 3 (March 2022): 467–76. https://doi.org/10.1016/j.cardfail.2021.10.011.
Coniglio AC, Patel CB, Kittleson M, Schlendorf K, Schroder JN, DeVore AD. Innovations in Heart Transplantation: A Review. J Card Fail. 2022 Mar;28(3):467–76.
Coniglio, Amanda C., et al. “Innovations in Heart Transplantation: A Review.J Card Fail, vol. 28, no. 3, Mar. 2022, pp. 467–76. Pubmed, doi:10.1016/j.cardfail.2021.10.011.
Coniglio AC, Patel CB, Kittleson M, Schlendorf K, Schroder JN, DeVore AD. Innovations in Heart Transplantation: A Review. J Card Fail. 2022 Mar;28(3):467–476.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

March 2022

Volume

28

Issue

3

Start / End Page

467 / 476

Location

United States

Related Subject Headings

  • United States
  • Tissue and Organ Procurement
  • Tissue Donors
  • Humans
  • Hepatitis C, Chronic
  • Hepatitis C
  • Heart Transplantation
  • Heart Failure
  • Cardiovascular System & Hematology
  • Antiviral Agents