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Coping strategies in patients with acute myeloid leukemia.

Publication ,  Journal Article
Amonoo, HL; Bodd, MH; Reynolds, MJ; Nelson, AM; Newcomb, R; Johnson, PC; Dhawale, TM; Plotke, R; Heuer, L; Gillani, S; Yang, D; Deary, EC ...
Published in: Blood Adv
April 12, 2022

Patients diagnosed with acute myeloid leukemia (AML) face sudden-onset life-threatening disease that requires intensive treatments. Although their early disease trajectory is characterized by significant, toxic side effects, limited data are available describing coping strategies among patients with AML and how these inform patient-reported outcomes. We used cross-sectional secondary data analyses to describe coping in 160 patients with newly diagnosed high-risk AML. The Brief COPE, Hospital Anxiety and Depression Scale, Post-Traumatic Stress Disorder Checklist-Civilian Version, and Functional Assessment of Cancer Therapy-Leukemia were used at time of AML diagnosis to measure coping strategies, psychological distress, and quality of life (QOL), respectively. The median split method for distribution of coping domains and multivariate regression models were used to assess the relationship between coping and patient-reported outcomes. Participants (median age, 64.4 years) were mostly non-Hispanic White (86.3%), male (60.0%), and married (73.8%). Most (51.9%) had high utilization of approach-oriented coping strategies, whereas 38.8% had high utilization of avoidant coping strategies. At time of diagnosis, use of approach-oriented coping was associated with less psychological distress (anxiety, β = -0.262, P = .002; depression symptoms, β = -0.311, P < .001; and posttraumatic distress disorder symptoms, β = -0.596, P = .006) and better QOL (β = 1.491, P = .003). Use of avoidant coping was associated with more psychological distress (anxiety, β = 0.884, P < .001; depression symptoms, β = 0.697, P < .001; and posttraumatic distress disorder symptoms, β = 3.048, P < .001) and worse QOL (β = -5.696, P < .001). Patients with high-risk AML use various approach-oriented and avoidant coping strategies at time of diagnosis. Use of approach-oriented coping strategies was associated with less psychological distress and better QOL, suggesting a possible target for supportive oncology interventions.

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Published In

Blood Adv

DOI

EISSN

2473-9537

Publication Date

April 12, 2022

Volume

6

Issue

7

Start / End Page

2435 / 2442

Location

United States

Related Subject Headings

  • Quality of Life
  • Middle Aged
  • Male
  • Leukemia, Myeloid, Acute
  • Humans
  • Cross-Sectional Studies
  • Anxiety
  • Adaptation, Psychological
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Chicago
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Amonoo, H. L., Bodd, M. H., Reynolds, M. J., Nelson, A. M., Newcomb, R., Johnson, P. C., … El-Jawahri, A. (2022). Coping strategies in patients with acute myeloid leukemia. Blood Adv, 6(7), 2435–2442. https://doi.org/10.1182/bloodadvances.2021005845
Amonoo, Hermioni L., Monica H. Bodd, Matthew J. Reynolds, Ashley M. Nelson, Richard Newcomb, Patrick Connor Johnson, Tejaswini M. Dhawale, et al. “Coping strategies in patients with acute myeloid leukemia.Blood Adv 6, no. 7 (April 12, 2022): 2435–42. https://doi.org/10.1182/bloodadvances.2021005845.
Amonoo HL, Bodd MH, Reynolds MJ, Nelson AM, Newcomb R, Johnson PC, et al. Coping strategies in patients with acute myeloid leukemia. Blood Adv. 2022 Apr 12;6(7):2435–42.
Amonoo, Hermioni L., et al. “Coping strategies in patients with acute myeloid leukemia.Blood Adv, vol. 6, no. 7, Apr. 2022, pp. 2435–42. Pubmed, doi:10.1182/bloodadvances.2021005845.
Amonoo HL, Bodd MH, Reynolds MJ, Nelson AM, Newcomb R, Johnson PC, Dhawale TM, Plotke R, Heuer L, Gillani S, Yang D, Deary EC, Daskalakis E, Goldschen L, Brunner A, Fathi AT, LeBlanc TW, El-Jawahri A. Coping strategies in patients with acute myeloid leukemia. Blood Adv. 2022 Apr 12;6(7):2435–2442.

Published In

Blood Adv

DOI

EISSN

2473-9537

Publication Date

April 12, 2022

Volume

6

Issue

7

Start / End Page

2435 / 2442

Location

United States

Related Subject Headings

  • Quality of Life
  • Middle Aged
  • Male
  • Leukemia, Myeloid, Acute
  • Humans
  • Cross-Sectional Studies
  • Anxiety
  • Adaptation, Psychological
  • 3201 Cardiovascular medicine and haematology