Skip to main content
Journal cover image

Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions.

Publication ,  Journal Article
Khoury, S; Parisien, M; Thompson, SJ; Vachon-Presseau, E; Roy, M; Martinsen, AE; Winsvold, BS; HUNT All-In Pain, ; Mundal, IP; Zwart, J-A ...
Published in: Brain
April 29, 2022

Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions. Whether chronic overlapping pain conditions represent a distinct pathophysiology from the occurrence of pain at only one site is unknown. Using genome-wide approaches, we compared genetic determinants of chronic single-site versus multisite pain in the UK Biobank. We found that different genetic signals underlie chronic single-site and multisite pain with much stronger genetic contributions for the latter. Among 23 loci associated with multisite pain, nine loci replicated in the HUNT cohort, with the DCC netrin 1 receptor (DCC) as the top gene. Functional genomics identified axonogenesis in brain tissues as the major contributing pathway to chronic multisite pain. Finally, multimodal structural brain imaging analysis showed that DCC is most strongly expressed in subcortical limbic regions and is associated with alterations in the uncinate fasciculus microstructure, suggesting that DCC-dependent axonogenesis may contribute to chronic overlapping pain conditions via corticolimbic circuits.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Brain

DOI

EISSN

1460-2156

Publication Date

April 29, 2022

Volume

145

Issue

3

Start / End Page

1111 / 1123

Location

England

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Neurogenesis
  • Netrin-1
  • Humans
  • Chronic Pain
  • Chronic Disease
  • Brain
  • 52 Psychology
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Khoury, S., Parisien, M., Thompson, S. J., Vachon-Presseau, E., Roy, M., Martinsen, A. E., … Diatchenko, L. (2022). Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. Brain, 145(3), 1111–1123. https://doi.org/10.1093/brain/awab359
Khoury, Samar, Marc Parisien, Scott J. Thompson, Etienne Vachon-Presseau, Mathieu Roy, Amy E. Martinsen, Bendik S. Winsvold, et al. “Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions.Brain 145, no. 3 (April 29, 2022): 1111–23. https://doi.org/10.1093/brain/awab359.
Khoury S, Parisien M, Thompson SJ, Vachon-Presseau E, Roy M, Martinsen AE, et al. Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. Brain. 2022 Apr 29;145(3):1111–23.
Khoury, Samar, et al. “Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions.Brain, vol. 145, no. 3, Apr. 2022, pp. 1111–23. Pubmed, doi:10.1093/brain/awab359.
Khoury S, Parisien M, Thompson SJ, Vachon-Presseau E, Roy M, Martinsen AE, Winsvold BS, HUNT All-In Pain, Mundal IP, Zwart J-A, Kania A, Mogil JS, Diatchenko L. Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions. Brain. 2022 Apr 29;145(3):1111–1123.
Journal cover image

Published In

Brain

DOI

EISSN

1460-2156

Publication Date

April 29, 2022

Volume

145

Issue

3

Start / End Page

1111 / 1123

Location

England

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Neurogenesis
  • Netrin-1
  • Humans
  • Chronic Pain
  • Chronic Disease
  • Brain
  • 52 Psychology
  • 42 Health sciences