SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest.

Journal Article (Journal Article)

Endosomes are important cellular compartments for sorting internalized cargo and immune sensing. In this issue, Wang et al describe a novel signaling pathway induced by endocytosed bacterial outer membrane vesicles, where sorting nexin 10 and caspase-5 act at the endosome to promote cytosolic exposure of LPS and initiate signaling to alter epithelial layer integrity. This study presents the first example of a specialized function for caspase-5, distinct from the inflammasome function executed by the closely related paralog caspase-4.

Full Text

Duke Authors

Cited Authors

  • Dickinson, MS; Coers, J

Published Date

  • December 15, 2021

Published In

Volume / Issue

  • 40 / 24

Start / End Page

  • e110128 -

PubMed ID

  • 34796973

Pubmed Central ID

  • PMC8672184

Electronic International Standard Serial Number (EISSN)

  • 1460-2075

Digital Object Identifier (DOI)

  • 10.15252/embj.2021110128

Language

  • eng

Conference Location

  • England