Precision Medicine: Towards Individualized Dosing in Pediatric Rheumatology.

Journal Article (Journal Article;Review)

Despite an increase in the number of available therapeutics, many children with rheumatic disease continue to experience active inflammatory disease and treatment failure. One reason for treatment failure is the lack of dosing paradigms to account for the wide between-patient variability in drug pharmacokinetics because of developmental changes or genetic polymorphisms that effect drug absorption, distribution, metabolism, and elimination. This review highlights several strategies to optimize dosing for biologic and nonbiologic disease-modifying antirheumatic drugs, including therapeutic drug monitoring, pharmacogenomics, and the use of pharmacokinetic/pharmacodynamic modeling.

Full Text

Duke Authors

Cited Authors

  • Balevic, SJ; Sagcal-Gironella, ACP

Published Date

  • February 2022

Published In

Volume / Issue

  • 48 / 1

Start / End Page

  • 305 - 330

PubMed ID

  • 34798954

Electronic International Standard Serial Number (EISSN)

  • 1558-3163

Digital Object Identifier (DOI)

  • 10.1016/j.rdc.2021.09.010


  • eng

Conference Location

  • United States