Impact of HIV on lung tumorigenesis in an animal model.
Publication
, Journal Article
Kawabata, S; Heredia, A; Gills, J; Redfield, RR; Dennis, PA; Bryant, J
Published in: AIDS
March 13, 2015
Many HIV patients on antiretroviral therapy have controlled viremia and restored (albeit partially) immunity. Yet, they have high rates of lung cancer, even after controlling for smoking. We tested the hypothesis that HIV proteins accelerate development/progression of lung cancer in an immunocompetent HIV transgenic mouse model. The expression of HIV proteins did not enhance lung tumorigenesis caused by two different tobacco carcinogens, suggesting that incompletely restored immunity and/or inflammation, which persist(s) in most HIV patients despite controlled viremia, underlie(s) excess risk of lung cancer. Adjuvant therapies that restore immunity and lower inflammation may decrease lung cancer mortality in HIV patients.
Duke Scholars
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
March 13, 2015
Volume
29
Issue
5
Start / End Page
633 / 635
Location
England
Related Subject Headings
- Virology
- Mice, Transgenic
- Lung Neoplasms
- HIV Infections
- Female
- Disease Models, Animal
- Carcinogens
- Carcinogenesis
- Animals
- 42 Health sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Kawabata, S., Heredia, A., Gills, J., Redfield, R. R., Dennis, P. A., & Bryant, J. (2015). Impact of HIV on lung tumorigenesis in an animal model. AIDS, 29(5), 633–635. https://doi.org/10.1097/QAD.0000000000000588
Kawabata, Shigeru, Alonso Heredia, Joell Gills, Robert R. Redfield, Phillip A. Dennis, and Joseph Bryant. “Impact of HIV on lung tumorigenesis in an animal model.” AIDS 29, no. 5 (March 13, 2015): 633–35. https://doi.org/10.1097/QAD.0000000000000588.
Kawabata S, Heredia A, Gills J, Redfield RR, Dennis PA, Bryant J. Impact of HIV on lung tumorigenesis in an animal model. AIDS. 2015 Mar 13;29(5):633–5.
Kawabata, Shigeru, et al. “Impact of HIV on lung tumorigenesis in an animal model.” AIDS, vol. 29, no. 5, Mar. 2015, pp. 633–35. Pubmed, doi:10.1097/QAD.0000000000000588.
Kawabata S, Heredia A, Gills J, Redfield RR, Dennis PA, Bryant J. Impact of HIV on lung tumorigenesis in an animal model. AIDS. 2015 Mar 13;29(5):633–635.
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
March 13, 2015
Volume
29
Issue
5
Start / End Page
633 / 635
Location
England
Related Subject Headings
- Virology
- Mice, Transgenic
- Lung Neoplasms
- HIV Infections
- Female
- Disease Models, Animal
- Carcinogens
- Carcinogenesis
- Animals
- 42 Health sciences