Impact of HIV on lung tumorigenesis in an animal model.

Journal Article (Journal Article)

Many HIV patients on antiretroviral therapy have controlled viremia and restored (albeit partially) immunity. Yet, they have high rates of lung cancer, even after controlling for smoking. We tested the hypothesis that HIV proteins accelerate development/progression of lung cancer in an immunocompetent HIV transgenic mouse model. The expression of HIV proteins did not enhance lung tumorigenesis caused by two different tobacco carcinogens, suggesting that incompletely restored immunity and/or inflammation, which persist(s) in most HIV patients despite controlled viremia, underlie(s) excess risk of lung cancer. Adjuvant therapies that restore immunity and lower inflammation may decrease lung cancer mortality in HIV patients.

Full Text

Duke Authors

Cited Authors

  • Kawabata, S; Heredia, A; Gills, J; Redfield, RR; Dennis, PA; Bryant, J

Published Date

  • March 13, 2015

Published In

Volume / Issue

  • 29 / 5

Start / End Page

  • 633 - 635

PubMed ID

  • 25611150

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

Digital Object Identifier (DOI)

  • 10.1097/QAD.0000000000000588


  • eng

Conference Location

  • England